What Is GHK-Cu?
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring copper peptide complex found in human plasma, saliva, and urine. First isolated in the 1970s, it has since become one of the most studied peptides in regenerative and anti-aging research due to its wide range of observed biological activity in preclinical models.
Areas of Active Research
- Skin biology — Research has explored GHK-Cu’s role in stimulating collagen and glycosaminoglycan synthesis, as well as its interaction with skin remodeling pathways.
- Wound healing — Preclinical studies have examined its effects on fibroblast activity and tissue repair mechanisms.
- Anti-inflammatory activity — GHK-Cu has been studied for its ability to modulate inflammatory gene expression, including downregulation of pro-inflammatory cytokines.
- Antioxidant pathways — Research suggests GHK-Cu may upregulate antioxidant defense systems, including superoxide dismutase activity.
- Gene expression — Studies have shown GHK-Cu can influence the expression of over 4,000 human genes, many associated with tissue restoration and anti-aging processes.
Mechanism of Action
GHK-Cu is believed to act as a biological signal that activates tissue remodeling and repair. The copper ion plays a critical role — it is essential for the activity of several enzymes involved in collagen cross-linking and antioxidant defense. The peptide component (GHK) facilitates copper transport into cells and modulates gene expression through interaction with transcription factors.
Research Form & Storage
GHK-Cu is typically supplied as a lyophilized powder for research use. It should be stored in a cool, dry environment prior to reconstitution and refrigerated after reconstitution to maintain stability.
Important Notice
GHK-Cu is available through Avivim Wellness strictly for laboratory and scientific research purposes. It is not intended for human consumption, therapeutic use, or diagnostic application.